Acsl4 t cell
WebApr 11, 2024 · ACSL4 arachidonic acid interferon oleic acid palmitoleic acid ferroptosis T cell immunotherapy PD-L1 cancer Introduction Ferroptosis was discovered by studying the cytotoxic effects of small synthetic molecules, such as erastin and RSL3, in cultured tumor cells in vitro ( Dixon and Stockwell, 2024 ). WebJan 13, 2024 · A new study demonstrates that the function of the lipid metabolic enzyme ACSL4 is positively regulated by phosphorylation, leading to amplification of ferroptotic cell death. These results shed...
Acsl4 t cell
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WebApr 22, 2024 · Overall, this study identifies IFNγ (secreted by CD8 + T cells) in combination with AA (taken up from the tumor microenvironment) as a novel natural FIN, and … WebNational Center for Biotechnology Information
WebJan 20, 2024 · ACSL4 is mainly present in peroxisome, mitochondria and endoplasmic reticulum. In contrast, ACSL4 prefers longer polyunsaturated fatty acids (PUFA) as substrates, such as arachidonic acid. WebFeb 24, 2024 · ACSL4-dependent tumor ferroptosis is a mode of action of CTLs • ACSL4 mediates immunogenic tumor ferroptosis • Targeting tumor ACSL4 sensitizes checkpoint therapy Summary Tumor cell intrinsic ferroptosis-initiating mechanisms are unknown.
WebApr 7, 2024 · Lipid peroxidation and ferroptosis regulate the viability and activity of CD8 + cytotoxic T cells and CD4 + helper T cells. [10, 11] Second, ... SLC3A2) and positively correlated with the ferroptosis promotion gene ACSL4 (Figure S5C,D, Supporting Information). A decrease in the expression of the ferroptosis inhibition genes ... WebTo identify distinct metabolic vulnerabilities of CD8 + T cells and cancer cells, we developed a high-throughput in vitro pharmacologic screening platform and used it to measure the …
WebAug 13, 2024 · ACSL4 is not only enhanced during ferroptosis but also required for cells to undergo ferroptotic cell death, at least in leukemia and liver cancer cells [12, 13].
WebFerroptosis is a regulated form of cell death characterized by iron dependency and increased lipid peroxidation. Initially assumed to be selectively induced in tumour cells, there is increasing evidence that ferroptosis plays an important role in pathophysiology and numerous cell types and tissues. Deregulated ferroptosis has been linked to human … jeff godwin rock musicWebFeb 8, 2024 · Acyl-CoA synthetase long-chain family member 4 (ACSL4), which is a key enzyme that regulates lipid composition, has been shown to contribute to the execution of ferroptosis, but its role in I/R... jeff goetheWebApr 22, 2024 · IFNγ secreted by CD8 + T cells binds to IFNR, activates the JAK-STAT1-IRF1 signaling axis, and induces ACSL4 expression in tumor cells. The increase in ACSL4 expression, in combination with AA supplementation, promotes AA containing-PL synthesis. In addition, IFNγ reduces SLC7A11 expression and weakens ferroptosis defense in … jeff goettman chief of staffWebApr 6, 2024 · Further investigations indicated that the expression of acyl-CoA synthetase long-chain family member 4 (ACSL4) increased in NP cells of the stiff group, which mediated lipid peroxidation and ferroptosis in NP cells. In addition, stiff substrate activated the Hippo signaling cascade and induced the nuclear translocation of yes-associated … oxford dtp applicationWebApr 11, 2024 · In this issue of Cancer Cell, Liao et al. demonstrate that CD8 + T cell-secreted interferon-gamma (IFN-γ) rewires cancer cell lipid metabolism via the enzyme acyl-CoA synthetase long-chain family member 4 (ACSL4). ACSL4 activates polyunsaturated fatty acids and sensitizes cancer cells to ferroptosis in immunotherapy-relevant settings. … oxford dunbar twill overcoatWebApr 22, 2024 · Tumor cell-intrinsic metabolic features can affect the cancer-immunity dialogue. In a recent paper published in Cancer Cell, Liao et al. demonstrate that IFNγ produced by T cells, together with arachidonic acid, can induce acyl-CoA synthetase long-chain family member 4 (ACSL4)-mediated ferroptosis, correlating with increased … oxford dual height stoolWebSep 15, 2024 · ACSL4 is generally considered to be universally required for ferroptosis, a form of cell death induced by phospholipid peroxidation. In this issue of Cell Chemical Biology, Magtanong et al. (2024) report the surprising finding that ACSL4 is only required for ferroptosis in certain circumstances, raising interesting questions about the regulation of … oxford duc