웹2006년 3월 1일 · Skeletal muscle has an increased mtDNA content and a decreased basal TK2 activity compared with other tissues. The molecular background for the tissue specificity in mtDNA depletion syndrome cases caused by TK2 vs the dGK deficiency may be related to altered capacity of the resting muscle and liver cells to salvage deoxynucleosides [36] .

10.1016/S1096-7192(03)00063-5 DeepDyve

웹2009년 12월 1일 · Finally, basal TK2 activity is very low in human muscle tissue compared to liver or heart and low TK2/COX and TK2/mtDNA ratios are observed in muscle [50]. This … 웹Most recent answer. Dear researcher, minimal promoter refers to a minimal sequence of a native promoter (mostly core promoter) that could express a downstream gene. So, that not mean minimal ... cd入れる袋 ダイソー

Thymidine Kinase 1 - an overview ScienceDirect Topics

웹Decreased mitochondrial thymidine kinase (TK2) activity is associated with mitochondrial DNA (mtDNA) depletion and respiratory chain dysfunction and is manifested by isolated, fatal skeletal myopathy. Other tissues such as liver, brain, heart, and skin remain unaffected throughout the patients' life. In order to elucidate the mechanism of tissue specificity in the … 웹2024년 5월 6일 · Background TK2 gene encodes for mitochondrial thymidine kinase, which phosphorylates the pyrimidine nucleosides thymidine and deoxycytidine. Recessive mutations in the TK2 gene are responsible for the ‘myopathic form’ of the mitochondrial depletion/multiple deletions syndrome, with a wide spectrum of severity. Methods We describe 18 patients … 웹2024년 3월 31일 · TK2) but not A549 cells (low TK2) to gemcitabine. Combined treatment with TK2 siRNA and gemcitabine increased dCK. We also hypothesized that TK2 siRNA-induced drug sensitization results in mitochondrial damage that enhances gemcitabine effectiveness. TK2 siRNA and gemcitabine decreased mitochondrial redox status, DNA content, and activity. cd 再利用 工作 カラス