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Bioisosteres in drug discovery: focus on tetrazole
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WebNov 25, 2024 · Conclusion. Tetrazole, the bioisoster of carboxylic acid, is an important pharmacophore in the development of novel drugs. Tens of tetrazole-containing compounds, such as cefamandole, ceftezole, tedizolid, letrozole, encequidar, oteseconazole, quilseconazole, losartan, valsartan, irbesartan, candesartan and tomelukast, have … WebExpert Advice. Biological waste treatment relies on billions of microbes to convert wastes into harmless forms. This is a complex process and Aster Bio's experts in biological … WebJan 30, 2024 · The objective of a bioisosteric replacement is to create a new molecule with similar biological properties to the parent compound. The bioisosteric replacement may be physicochemically or topologically based. The replacement can attenuate toxicity, modify activity of lead, and/or alter pharmacokinetics or the toxicity of the lead. how many carbohydrates in 1 tsp sugar