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WebThe apical ectodermal ridge is a region of thickened epithelium at the most distal end of the limb bud. The zone of polarising activity (ZPA) is at the posterior part of the limb bud. The apical ectodermal ridge ( AER) is a structure that forms from the ectodermal cells at the distal end of each limb bud and acts as a major signaling center to ... Webstage in the development of the lower limb bud takes place several days later than in the upper limb bud. 2. At early bud stages, the limbs have the appearance of flippers. The upper buds appear dispro-portionately low on the trunk due to the initial domi-nance of the head and neck region of the embryo. 3. Initial elongation begins around day 33 lakia rapper
Apical ectodermal ridge - Wikipedia
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