WebResearch assistant in Dr. Janet Neisewander's neuroscience of substance abuse lab at Arizona State University. I lead and managed a project studying the effects of the circRNA circHomer1 on ... WebCircHOMER1 was highly expressed in HG-induced HMCs and DN patients. Downregulation of circHOMER1 suppressed oxidative stress, inflammation and ECM deposition in HMCs induced by HG. In terms of mechanism, circHOMER1 could sponge miR-137 to regulate SOX6. Function assays showed that miR-137 inhibitor or SOX6 overexpression revoked …
"Effects of neuronal activation and psychiatric treatment on circHomer1 …
WebJan 18, 2024 · In order to examine whether alterations in circHomer1 are associated with the expression of specific HOMER1 mRNA isoforms, we used isoform-specific quantitative real-time PCR in postmortem samples from the OFC of subjects with BD (n = 30), SCZ (n = 32), and unaffected controls (n = 33) derived from the Stanley Medical Research Institute … WebThe results showed that circHOMER1 inhibited adipogenic differentiation of porcine preadipocytes and suppressed adipogenesis in mice. Dual-luciferase reporter gene, RIP, and pull-down assays demonstrated that miR-23b directly bound to circHOMER1 and the 3'-UTR of SIRT1. Rescue experiments further illustrated the regulatory relationship among ... garmin bnc connector
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WebCircHOMER1 has been identified to be associated with the pathogenesis of CRC. 18 Zhao et al revealed that miR-138-5p functioned as a tumor suppressor to inhibit CRC cell growth via decreasing PD-L1. 30 In this study, we demonstrated, lidocaine-induced cell viability loss, apoptosis induction and aerobic glycolysis suppression in CRC could be ... WebJan 18, 2024 · Here, we show that deficits in circHomer1 levels within the OFC and iPSC-derived neuronal cultures of patients with psychiatric disorders are inversely associated with the relative expression of the long HOMER1B mRNA isoform. Using in vivo circHomer1- and Homer1b-specific KD in mouse OFC, we demonstrate that mature circHomer1 and … WebFeb 21, 2024 · Circular RNAs (circRNAs) are ideal biomarkers and are involved in adipogenesis. Here, we investigated the effect and mechanism of circHOMER1 on porcine adipogenesis in vitro and in vivo. Western blotting, Oil red O staining, and HE staining were used to assess the function of circHOMER1 in adipogenesis. black pvc raincoat images