WebApr 28, 2002 · Elevated levels of GSH render some types of cancer cells resistant against well-known platinum anti-cancer drugs such as cisplatin and carboplatin. Platinum complexes are often very reactive towards the cysteine residue of GSH, which detoxifies these compounds by a rapid binding mechanism. WebFeb 1, 2005 · Cisplatin is the first choice treatment in mediastinal germ cell tumors. However, concerns regarding increased toxicity of cisplatin hamper its administration in …
Molecules Free Full-Text The Challenging Treatment of Cisplatin ...
WebJul 7, 2014 · Cisplatin exerts its toxicity by DNA binding and downstream apoptotic signaling, and resistance is conferred by reducing apoptotic signaling, up-regulating DNA … WebEffect of cisplatin-induced acute renal failure on bioavailability and intestinal secretion of quinolone antibacterial drugs in rats Cisplatin-induced ARF differentially modulated the bioavailability and intestinal secretion of quinolones in rats. crossword clue showing no sign of life
Effect of cisplatin-induced acute renal failure on bioavailability …
WebMay 13, 2024 · To improve the bioavailability and tolerance of drugs, recent advances in nanotechnology promote the development of nanoparticle-based drug delivery systems, which is widely used in cancer chemotherapy (Lepeltier et al., 2024; Su et al., 2024). Nanoparticles have advantages including good biocompatibility, low toxicity, long … WebMar 26, 2024 · The current evidence prompted that Lentinan combined with cisplatin in thoracic injection might benefit patients with NSCLC on a certain extent; this systematic review revealed some definite conclusions about the application of Lentinan combined with cisplatin in thoracic injection for NSCLC. WebJan 1, 1985 · Cisplatin is generally synthesised by the ammonolysis of potassium tetrachloroplatinate (K 2 PtC1 4 ). The absorption spectrum of cisplatin (1.0 mg/ml) has been obtained in 0.1 N HCl using a Cary 15 and 2.0 cm cells.The spectrum shows three maxima at 203 nm, 301 nm, and 362 nm, a “shoulder” at 285 nm, and minima at 246 nm … crossword clue showy bloom