Cisplatin nrf2
WebJul 31, 2024 · Radiation-induced intestinal injuries (RIII) commonly occur in patients who suffer from pelvic or abdominal cancer. Nuclear factor-erythroid 2-related factor 2 (Nrf2) is a key transcriptional regulator of antioxidant, and the radioprotective role of Nrf2 is found in bone marrow, lung, and intestine, etc. Here, we investigated the effect of Nrf2 knockout … WebNov 27, 2024 · Cisplatin is the first-line chemotherapy treatment for those patients, however, resistance to this drug is a common and yet not fully understood phenomenon. Aiming to shed new light into this … The balance between NRF2/GSH antioxidant mediated pathway and DNA repair modulates cisplatin resistance in lung cancer cells
Cisplatin nrf2
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WebKey results: Nrf2 deletion induced ferroptosis-related protein expression and iron accumulation in vivo, aggravating cisplatin-induced acute kidney injury. Leonurine activated Nrf2 and prevented iron accumulation, lipid peroxidation and ferroptosis in vitro, being abolished in siNrf2-treated cells. WebAbstract: ObjectiveTo investigate the effect of cisplatin on the protein expression and nuclear translocation of Nrf2, and on the changes of autophagy and apoptosis in HeLa …
WebResults: Metformin was observed to synergistically augment cisplatin-induced cytotoxicity by strongly inhibiting the level of Nrf2, thereby weakening the antioxidant system and detoxification ability of Nrf2 and enhancing ROS-mediated apoptosis in NSCLC. The synergistic antitumor effect of combination therapy is blocked by treatment with the ... WebSep 18, 2024 · NCBI Bookshelf
WebNov 11, 2024 · Farrerol Ameliorated Cisplatin-Induced Chronic Kidney Disease Through Mitophagy Induction via Nrf2/PINK1 Pathway Previously, Our study has showed that farrerol can activate Nrf2 and ameliorate cisplatin-induced acute kidney injury (AKI). Mitophagy reportedly can prevent diabetic nephropathy, cisplatin-induced AKI and other related … WebNrf2 genetic silencing or trigonelline reversed the ferroptosis resistance of Keap1-silenced and cisplatin-resistant HNC cells to artesunate in vitro and in vivo. Nrf2-ARE pathway activation contributes to the artesunate resistance of HNC cells, and inhibition of this pathway abolishes ferroptosis-resistant HNC. Condensed abstract:
WebMay 16, 2014 · Nuclear factor erythroid 2-related factor 2 (Nrf2) is over-expressed in many types of tumor, promotes tumor growth, and confers resistance to anticancer therapy. Hence, Nrf2 is regarded as a novel therapeutic target in cancer. Previously, we reported that luteolin is a strong inhibitor of Nrf2 in vitro.
WebApr 1, 2024 · Alginate oligosaccharide is the depolymerized product of alginate, a natural extract of brown algae, which is associated with beneficial health effects. Here, we aimed to investigate the mechanism via which alginate oligosaccharides improve kidney oxidative damage and liver inflammation induced by cisplatin chemotherapy via the gut … diabetic blind and deafWebLoss of Scribble confers cisplatin resistance during NSCLC chemotherapy via Nox2/ROS and Nrf2/PD-L1 signaling Our study revealed that polarity protein Scribble increased cisplatin-induced ROS generation and is beneficial to chemotherapeutic outcomes in … diabetic bleedingWebThe inhibition of Nrf2 has been found to result in increased sensitivity while its activationresults in increased resistance in human cisplatin resistant cancer cells. 34 Overall, the enhanced level of Nrf2 seems to be preventive in initial stages while in advanced or malignant stages of cancer increased levels have been shown to protect the ... cindy larnedWebAug 20, 2024 · The unsupervised heat map analysis showed that Nrf2 target genes SOD2, SLC3A1, AKRC1, GCLC, HO-1, NQO1, and SOD1 were highly upregulated in the cisplatin-resistant tumor cells compared to the ... cindy large saffiano leather crossbody blackWebApr 1, 2024 · Alginate Oligosaccharide Alleviated Cisplatin-Induced Kidney Oxidative Stress via Lactobacillus Genus-FAHFAs-Nrf2 Axis in Mice Alginate Oligosaccharide Alleviated Cisplatin-Induced Kidney Oxidative Stress via Lactobacillus Genus-FAHFAs-Nrf2 Axis in Mice Front Immunol. 2024 Apr 1;13:857242. doi: 10.3389/fimmu.2024.857242. … cindy larsen facebookWebFeb 2, 2024 · Recently, a large number of articles have found that agents including edaravone and epigallocatechin-3-gallate (EGCG) prevented the development of … cindy large saffiano leather crossbodyWebOur results indicated that similar to NRF2, cisplatin-induced reduction of MDM2 was also significantly blocked by ω-3 PUFAs. Inhibition of NRF2 activity abolished ω-3 PUFAs-induced expression of MDM2, and stimulated p53 expression in BM cells (Fig. 8). Together, these results indicate that NRF2 is a positive transcriptional regulator of MDM2 ... diabetic blister