Cisplatin renal injury

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August undefined, 2024

WebFeb 5, 2010 · It is the urinary concentrations of furosemide that determine its diuretic effect. The severity of acute kidney injury has a significant effect on the diuretic response to furosemide; a good ‘urinary response’ may be considered as a ‘proxy’ for having some residual renal function. WebSurgery-induced renal ischemia and reperfusion (I/R) injury and nephrotoxic drugs like cisplatin can cause acute kidney injury (AKI), for which there is no effective therapy. …

Mechanisms of Cisplatin-Induced Acute Kidney Injury: Pathological ...

WebA known complication of cisplatin administration is acute kidney injury (AKI). The nephrotoxic effect of cisplatin is cumulative and dose-dependent and often necessitates … WebThe cisplatin-treated rats exhibited acute structural damage characterized by tubular necrosis, swelling and tubular dilation, extensive epithelial vacuolization, and hyaline casts in renal... green lake county clerk of courts

C57BL/6 mice require a higher dose of cisplatin to induce renal ...

WebSurgery-induced renal ischemia and reperfusion (I/R) injury and nephrotoxic drugs like cisplatin can cause acute kidney injury (AKI), for which there is no effective therapy. Lipid accumulation is evident following AKI in renal tubules although the mechanisms and pathological effects are unclear. Here, we report that Ehmt2-encoded histone ... WebOct 1, 2024 · Indepth analyses of this intra-animal variability revealed C-C motif chemokine ligand 2 as a marker of cisplatin-induced kidney injury through correlation studies. In … WebApr 25, 2014 · Most of the cisplatin is trapped within the renal cortex [13, 22]. The concentration of cisplatin in the proximal tubular cells is 5 times higher than the serum … green lake county clerk of court

Benefits and risks of furosemide in acute kidney injury

Rapamycin Perfluorocarbon Nanoparticle Mitigates Cisplatin …

WebJul 22, 2024 · Cisplatin is a potent and valuable chemotherapy agent used to treat a broad spectrum of malignancies. Renal tubular dysfunction and a cumulative impairment in … WebAims: This study investigated the regulatory effect of Mitofusin2 (Mfn2) on mitochondria-associated endoplasmic reticulum membrane (MAMs) integrity and cellular injury in … green lake county assessor property searchWebOct 1, 2024 · Cisplatin is a potent chemotherapeutic used for the treatment of many types of cancer. However, its dose-limiting side effect is nephrotoxicity leading to acute kidney … flyer this week

"WebOct 22, 2024 · We hypothesized that cisplatin, an anticancer drug that generally causes DNA damage and cell death in rapidly proliferating cells, exacerbates DNA damage in regenerative proliferating renal... " - Cisplatin renal injury

Cisplatin renal injury

Pathophysiology of Cisplatin-Induced Acute Kidney Injury - Hindawi

WebRenal injury induced by cisplatin primarily occurs in proximal tubules, 1 where the tubular injury causes a decrease in the glomerular filtration rate. 2 Because of this decrease in the glomerular filtration rate, the elimination of cisplatin is delayed in patients with cancer, and, as a result, tubular and glomerular injuries subsequently develop. WebJan 29, 2024 · Besides, pretreatment of paricalcitol could also alleviated Erastin (an inducer of ferroptosis) induced cell death in HK-2 cell. These data suggested that ferroptosis …

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WebAims: This study investigated the regulatory effect of Mitofusin2 (Mfn2) on mitochondria-associated endoplasmic reticulum membrane (MAMs) integrity and cellular injury in cisplatin-induced acute kidney injury (CP-AKI). Results: CP- AKI mice exhibited decreased expression of Mfn2, increased expression of phosphorylated adenosine … WebDec 21, 2024 · Acute kidney injury (AKI) is an ominous clinical–pathologic state associated with the abrupt loss of renal functions and consequential complications. It is estimated that more than 20–50% of hospitalized patients are affected by various episodes of AKI [ 1 ].

WebMar 23, 2024 · For nearly five decades, cisplatin has played an important role as a standard chemotherapeutic agent and been prescribed to 10-20% of all cancer patients. Although nephrotoxicity associated with platinum-based agents is well recognized, treatment of cisplatin-induced acute kidney injury is mainly su … WebOct 13, 2024 · Cisplatin is nephrotoxin that can cause both acute kidney injury and chronic kidney disease. Accumulation of cisplatin in renal tubular cells induces various intracellular stresses,...

WebApr 1, 2024 · Acute kidney injury (AKI) remains a major global healthcare problem, and there is a need to develop human-based models to study AKI in vitro. Toward this goal, … WebJul 31, 2014 · Although the severity of cisplatin-induced nephrotoxicity is reduced following genetic or pharmacologic knockout of Oct1 and Oct2, renal tubular damage is not completely abolished. This suggests the existence of a secondary pathway that contributes, independently of Oct1/Oct2-mediated renal tubular drug uptake, to cisplatin-induced …

WebApr 3, 2024 · As a result, renal injury is the most serious adverse effect restricting the application of cisplatin [ 4 ]. The prevalence of CP-induced acute kidney injury (CP-AKI) is approximately 31% to 68% in patients using cisplatin [ 5 ]. CP-AKI is characterized by tubular damage and acute renal dysfunction [ 6 ].

WebRenal injury induced by cisplatin primarily occurs in proximal tubules, 1 where the tubular injury causes a decrease in the glomerular filtration rate. 2 Because of this decrease in … green lake county court casesWebMar 20, 2024 · Background The reality of cisplatin-induced acute kidney injury (CIA) and its effects on long-term renal function remain unclear. The aim of this study was to … flyer this week maxiWebCisplatin is an antitumor drug used in the treatment of a wide variety of malignancies. However, its primary dose-limiting side effect is kidney injury, which is a major clinical concern. To help understand mechanisms involved in the development of kidney injury, cisplatin rodent model has been developed. flyer therapieWebMar 29, 2024 · Mechanisms of Cisplatin-Induced Acute Kidney Injury: Pathological Mechanisms, Pharmacological Interventions, and Genetic Mitigations Cancers (Basel). … green lake county clerk of courts faxWebCisplatin (CP)-induced nephrotoxicity is widely accepted as a model for acute kidney injury (AKI). Although cisplatin-induced chronic kidney disease (CKD) in rodent has … flyer this week for walmartWebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different … flyerthonWebNational Center for Biotechnology Information green lake county clerk of courts wi