Cisplatin toxicity prevention

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August undefined, 2024

WebFeb 1, 2024 · Cisplatin injection is used to treat advanced cancer of the bladder, ovaries, or testicles. Cisplatin is an antineoplastic agent (cancer medicine). It interferes with the growth of cancer cells, which are eventually destroyed by the body. This medicine is to be given only by or under the direct supervision of a doctor. WebChemotherapy is one of the most important treatment methods, especially for advanced NSCLC. 3 We conducted clinical retrospective observational analyses to observe the …

Review on Pharmacology of Cisplatin: Clinical Use, Toxicity and ...

WebSep 1, 1999 · The most important dose-limiting toxicity has been neurotoxicity. In one of these studies, Le Chevalier treated 32 patients at five dose levels. Neurotoxicity appeared to be dose-limiting, with 200 mg/m² of paclitaxel and 100 mg/m² of cisplatin defined as the maximum tolerated dose. Neurotoxicity was observed earlier with higher doses. [4] WebSep 3, 1991 · Three-year follow-up is now available. Twenty-one (77.8%) remitted completely following treatment, and 11 remain free of local and regional relapse at 3 … high waist leggings plus size

Mechanisms of Cisplatin-Induced Ototoxicity and Prevention

WebSep 20, 2024 · Patients were randomized (1:1) to receive cisplatin-based chemotherapy with or without sodium thiosulfate administered at various doses of 10 g/m2, 15 g/m2, or … WebReductions in antioxidant capacity with respect to corresponding controls were also restored by OLE treatment. These findings suggest that the OLE treatment against cisplatin-induced toxicity improves the function of blood cells and helps them to survive in the belligerent environment created by free radicals. WebNov 26, 2024 · It is mainly focused on four drugs: Cisplatin, Methotrexate, Doxorubicin, and Bleomycin. (3) Results: In experimental models and the few existing clinical studies, modulation of free radicals and antioxidants by ozone therapy was associated with decreased chemotherapy-induced toxicity. high waist linen shorts

A Systematic Review of Strategies to Prevent Cisplatin-Induced ... - PubMed

WebJul 22, 2024 · Cisplatin-induced kidney toxicity is reviewed here. The use of cisplatin in patients with pre-existing kidney dysfunction and the kidney effects of the platinum … WebSep 15, 2024 · Cisplatin is the prototype platinum coordination complex classified as an alkylating agent and used intravenously in the treatment of several forms of cancer. … how many equal sides does a kite haveWebDec 1, 2024 · Cisplatin’s effectiveness is limited as it causes liver toxicity. • Various natural antioxidants protect against cisplatin-induced hepatotoxicity. • Hepatoprotective mechanisms are antioxidant, anti-inflammatory, and anti-apoptosis. and scavenge free radicals in the liver after cisplatin administration. high waist light support pants

"WebCisplatin is a platinum-based chemotherapeutic that has long since been effective against a variety of solid-cancers, substantially improving the five-year survival rates for cancer patients. Its use has also historically been limited by its adverse drug reactions, or cisplatin-induced toxicities (CITs). Of these reactions, cisplatin-induced nephrotoxicity (CIN), … " - Cisplatin toxicity prevention

Cisplatin toxicity prevention

Concurrent cisplatin, infusional fluorouracil, and conventionally ...

WebApr 26, 2024 · Amifostine has FDA-approved labeling for use in reducing cumulative renal toxicity in patients receiving repeat doses of cisplatin for advanced ovarian cancer and … WebApr 12, 2024 · Progression-free survival (PFS) was 8 and 5 months in the cisplatin plus gemcitabine cohort and the gemcitabine cohort (p < .001), respectively. 4 Based on the …

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WebDec 1, 2024 · Dietary intervention is one of the anticipation ways for prevention of anti-cancer-related toxicity to minimize the harmful effects of cisplatin. Natural products or … Webthe treatment or may appear after months or years of treatment. Mild myocardiocyte injury in children has ... toxicity of Cisplatin in a median follow up time of 58 months identified cardiovascular risk factors in one third of patients with high cholesterol levels with and without obesity, and 15% with arterial hypertension, whereas 20% ...

National Center for Biotechnology Information WebJul 3, 2024 · Cisplatin is widely used for the treatment of a number of solid malignant tumors. However, ototoxicity induced by cisplatin is an obstacle to effective treatment of …

WebAbstract. Cisplatin has dramatically improved the survival rate of cancer patients, but it has also increased the prevalence of hearing and neurological deficits in this population. … WebSep 3, 1991 · After a preliminary dose-finding study involving 12 patients with advanced or locally recurrent head and neck cancer, 27 patients were treated on a phase II protocol, using fluorouracil 350 mg/m2/d by continuous intravenous (IV) infusion over 5 days, followed on the sixth day by a 2-hour IV infusion …

WebFeb 11, 2024 · Forty-four percent of patients developed cisplatin-regimen toxicity: 15% developed cisplatin-induced nephrotoxicity, 9% cisplatin-induced ototoxicity and 27% …

WebAug 22, 2015 · The standard approach for prevention of CIN is the administration of lower doses of cisplatin in combination with full intravenous hydration prior and after cisplatin administration. Cisplatin-induced oxidative stress in the kidney may be prevented by natural antioxidant compounds. high waist linen trousersWebMar 15, 2024 · Cisplatin and other platinum salt agents, including carboplatin and oxaliplatin, are widely used chemotherapy agents in patients with solid malignancies. … how many equal sides does a heptagon haveWebMay 8, 2024 · Deliver hydration to patients receiving cisplatin therapy to maintain renal function. Include magnesium supplementation, which has nephroprotective effects in … high waist lingerie setWebOct 7, 2024 · Cisplatin is one of the most widely used chemotherapeutic drugs in the treatment of a wide range of pediatric and adult malignances. However, it has various side effects which limit its use. Cisplatin mouse models are widely used in studies investigating cisplatin therapeutic and toxic effects. how many er for raiden shogunWebApr 12, 2024 · Currently, gemcitabine/cisplatin is first-line therapy for advanced iCCA based on the ABC-02 clinical trial (ClinicalTrials.gov identifier NCT02170090). That phase 3 study included 410 patients with locally advanced or metastatic CCA, gallbladder cancer, or ampullary cancer. high waist lingerieWebThe major toxicities of a cisplatin overdose include nausea and vomiting, renal insufficiency, electrolyte abnormalities, myelosuppression, ototoxicity, peripheral … how many er visits per year in usWebCisplatin is a clinically advanced and highly effective anticancer drug used in the treatment of a wide variety of malignancies, such as head and neck, lung, testis, ovary, breast … how many eragon movies are there