Citron homology
WebCitron homology (CNH) domain CRIB domain KELK-motif containing domain Myotonic dystrophy protein kinase, coiled coil PH-like domain superfamily Pleckstrin homology domain Protein kinase, ATP binding site Protein kinase C … WebJul 9, 2001 · Here, we report the identification of a novel human protein, hVam6p, that promotes lysosome clustering and fusion in vivo. Although hVam6p exhibits homology to the Saccharomyces cerevisiae vacuolar protein sorting gene product Vam6p/Vps39p, the presence of a citron homology (CNH) domain at the NH 2 terminus is unique to the …
Citron homology
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WebSep 20, 2024 · The CNH domain plays an essential role as a stabilizer for the small GTPase Rho1, a key regulator of glucan biosynthesis. This work provides a model … WebMembers of this subfamily contain an N-terminal catalytic domain and a C-terminal citron homology (CNH) regulatory domain. MAP4K4 is also called Nck Interacting kinase (NIK). It facilitates the activation of the MAPKs, extracellular signal-regulated kinase (ERK) 1, ERK2, and c-Jun N-terminal kinase (JNK), by phosphorylating and activating MEKK1.
WebNov 3, 2010 · GCK proteins are characterized by an N-terminal kinase domain and a C-terminal citron homology (CNH) domain separated by a variable region of lower sequence homology (Dan et al., 2001). MINK and TNIK specifically bind to Rap2 via their CNH domains ( Taira et al., 2004 ; Nonaka et al., 2008 ). WebApr 15, 2013 · Citron-K is a multiple domain protein containing an N-terminal kinase domain, an internal coiled-coil (CC) domain with Rho/Rac interacting site, and a C …
WebSep 21, 2024 · Rom2, the guanine nucleotide exchange factor to Rho1, contains a C-terminal citron homology (CNH) domain of unknown function that is found in many other … WebMost importantly, MRCKs, ROCKs, and CRIK contain a number of additional protein domains with distinct functions, including a small GTPase binding domain, a PH domain, a cysteine-rich domain, and a citron homology domain. It is this lack of motifs with known function that renders DMPK unique among its family members and in the AGC group as …
WebComparison Matrix. Gene Expression + Phenotype. Homozygotes for a null mutation are 20% smaller than wild-type and exhibit tremors, ataxia, and fatal seizures. Brains of …
WebHuman TNIK is a 1360-residue protein consisting of an N-terminal kinase domain, an intermediate domain, and a Cterminal domain conserved in the GCK family, which is termed the citron homology (CNH ... leon koen pesmeWebcitron homology (CNH) domain of unknown function that is found in many other eukaryotic genes. Here, we show that the Rom2 CNH domain interacts directly with … avion lisa marieWebNov 19, 2004 · TNIK possesses an N-terminal kinase domain homologous to STE20, the Saccharomyces cerevisiae mitogen-activated protein kinase kinase kinase kinase, and … leon kula potteryWebMar 2, 2024 · This protein is localized to the plasma membrane by means of the citron homology domain, where the middle region binds to CK2, thus preventing it from … avi-on loginhttp://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00036 avion kit polystyrèneWebJul 9, 2001 · Here, we report the identification of a novel human protein, hVam6p, that promotes lysosome clustering and fusion in vivo. Although hVam6p exhibits homology … leon kushner torontoWebMar 2, 2024 · Another important region identified was the citron homology domain located at the end of the protein. Through fluorescent imaging, it was discovered that this domain … avion kino