WebApr 15, 2024 · Argininosuccinate synthase (ASS1) is a ubiquitous enzyme in mammals that catalyzes the formation of argininosuccinate from citrulline and aspartate. ASS1 genetic … WebJan 10, 2024 · Citrulline depletion by ASS1 is required for proinflammatory macrophage activation and immune responses January 2024 Authors: Youxiang Mao Di Shi Gen Li …
Arginine depletion as a therapeutic approach for
WebFeb 5, 2024 · Multiple KSHV-encoded microRNAs upregulate argininosuccinate synthase 1 (ASS1), a key enzyme in the citrulline-NO cycle. ASS1 is required for KSHV-induced … WebFeb 3, 2024 · Citrulline depletion by ASS1 is required for proinflammatory macrophage activation and immune responses Youxiang Mao, Di Shi, Gen Li, Peng Jiang Mao et al. showed that phosphorylation and transcriptional upregulation of ASS1 mediated by JAK2 and STAT1, respectively, to deplete citrulline is essential for proinflammatory … philtaylorphs
Arginine deprivation using pegylated arginine deiminase has …
WebMar 30, 2024 · (D) The impact of ATG7 knockdown on the colony formation of ESCC cells with PSMD2 depletion. The cells were seeded into 6-well plates with a density of 1000 cells per well. After being cultured for 14 days, the cells were stained with crystal violet. N=3. The data were presented as mean ± SD. WebJul 15, 2024 · Depletion of arginine has been used by tumor cells to generate an immunosuppressive micro-environment. Cancer cells release factors (G-CSF, GM-CSF, … WebJun 25, 2015 · Tumor cells that lack ASS1 are therefore dependent on exogenous arginine, which in normal circumstances is available from the extracellular environment. 4-6 However, ASS1-negative tumor cells are potentially vulnerable to systemic arginine depletion, having no means to synthesize their own. t shirt zielony