Cytosolic phospholipase
WebThe secretory phospholipase A2IIa (sPLA2IIa) is an important inflammatory enzyme that catalyse the hydrolysis of membrane phospholipids into arachidonic and … WebMar 29, 2012 · Anti-Cytosolic Phospholipase A2 antibody (ab73406) at 1 µg/ml + HeLa Whole Cell Lysate - Bleomycin Treated (40U/ml) at 10 µg Secondary Goat polyclonal to …
Cytosolic phospholipase
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WebCytosolic phospholipase A2 is an enzyme that in humans is encoded by the PLA2G4A gene. [5] [6] Function [ edit] This gene encodes a member of the cytosolic … WebJun 1, 2024 · Phospholipase A 2 (PLA 2) enzymes recognize the sn-2 acyl bond of glycerophospholipids and hydrolyze the bond. The cytosolic PLA 2 (cPLA 2) enzyme is activated by various inflammatory stimuli and preferentially cleaves arachidonic acid (AA) from membrane phospholipid ( Kudo and Murakami, 2002; Ghosh et al., 2006 ).
WebSep 7, 2010 · Cytosolic phospholipase A2 alpha structure and activation. The binding of calcium (Ca 2+) ions to the CalB motif of the C2 domain promotes the translocation of cPLA 2 α from the cytosol to the perinuclear/membrane region of the cell. Following this change in subcellular localization, cPLA 2 α is phosphorylated on key serine residues of the … WebMar 28, 2024 · These observations suggest that cytosolic Tli is required for the activation and/or export of Tle. We show that Tle growth inhibition activity remains Tli-dependent when phospholipase delivery into target bacteria is ensured through fusion to the VgrG β-spike protein. Together, these findings indicate that Tli has distinct functions depending ...
WebCytosolic phospholipase A2, group IVa, (cPLA2, also known as cPLA2a, PLA2G4A) is a member of the PLA2 superfamily that catalyses the cleavage of fatty acids from the sn-2 position of phospholipids. PLA2 isoenzymes vary in their cellular localizations, Ca 2+ sensitivities and substrate specificities. cPLA2 mRNA is widely expressed in tissues and ... WebThe phospholipase A 2 enzymes are sources of cellular arachidonic acid, and the enzymes cyclooxygenase-2 (COX-2) and microsomal PGE synthase-1 (mPGES-1) are essential …
WebCytosolic phospholipase A(2) (cPLA(2)) is identified as a central molecule in NKG2D-mediated cytolysis in cytotoxic T lymphocytes. cPLA2 and IIbbeta3 interact to reinforce …
WebApr 18, 2024 · Cytosolic phospholipase A2 (cPLA2) has been reported to be critical for infection-induced mitochondrial reactive oxygen species (ROS) production and diaphragm dysfunction (DD). In the present study, we aim to investigate whether cPLA2 was involved in ventilator-induced diaphragm dysfunction (VIDD). Our results showed that mechanical … the outcastePhospholipases A2 include several unrelated protein families with common enzymatic activity. Two most notable families are secreted and cytosolic phospholipases A2. Other families include Ca independent PLA2 (iPLA2) and lipoprotein-associated PLA2s (lp-PLA2), also known as platelet activating factor acetylhydrolase (PAF-AH). The extracellular forms of phospholipases A2 have been isolated from different venoms (snake, bee, … shuler elementary cliveWebMar 1, 2014 · Here, we show that cytosolic phospholipase A 2 ε (cPLA 2 ε, also known as PLA2G4E) is targeted to the membrane compartments of the clathrin-independent endocytic route through a C-terminal stretch of positively charged amino acids, which allows the enzyme to interact with phosphoinositide lipids [especially PI (4,5)P 2] that are enriched … shuler elementary schoolWeb• Cytosolic phospholipase A 2 inhibitors might be useful for topical application against diseases such as atopic dermatitis or psoriasis. • Secreted phospholipase A 2 inhibitors varespladib and varespladib methyl are currently studied for … shuler fieldWebMar 13, 2001 · To clarify the role of AA in tumorigenesis, we have examined the effect of deleting the group IV cytosolic phospholipase A 2 (cPLA 2) locus (Pla2g4). We report … the outcaste pdfWebMay 1, 2004 · Phospholipase A 2 type IVA (IVAPLA 2) is a cytosolic enzyme that on activation selectively releases arachidonic acid (AA) from cell membrane phospholipids.Both AA and lysophospholipid, products of the enzymic reaction, can function as signal transducers in cellular interactions. The enzyme is present in most cells, including … the outcast ep 1 eng subWebMar 12, 2024 · PLA2G4A encodes for the cytosolic phospholipase A2α (cPLA2α), which is the rate-limiting enzyme in phospholipid metabolism and plays an important role during tumorigenesis. 3 However, the pathogenic role of PLA2G4A in FLT3-mutated AML is still elusive. Open in a separate window. the outcast dead horus heresy