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Glut1 overexpression

WebJun 1, 2004 · The overexpression of Glut1 in human cancers is known to be closely related to 18 F-FDG uptake in PET (10–12), though there is a controversial report ().Several immunohistochemical studies have demonstrated overexpression of Glut1 in human malignancy and a correlation between Glut1 expression and neoplastic progression … WebJun 20, 2024 · Overexpression of LAIR-1 in OS cells inhibits Glut1 expression and may further regulate glucose metabolism, thus inhibiting EMT and OS progression. Conclusions The findings of our study demonstrated that LAIR-1 are overexpressed in human OS tissues and that LAIR-1 expression is significantly higher in the T2 stage OS tumor than in the …

MUC16 promotes EOC proliferation by regulating GLUT1 expression

WebSIRT1 overexpression or GLUT1 overexpression alone was sufficient to promote cell proliferation and glucose uptake in BC cells. EX527, a specific inhibitor of SIRT1, exerted an opposing effect on bladder cancer proliferation and glucose uptake. The effect of EX527 could be partially reversed by GLUT1 overexpression. WebApr 21, 2024 · Cardiac-specific overexpression of Glut1, the embryonic form of constitutively active glucose transporter, resulted in an increase in glucose uptake and concomitant … jed juele https://traffic-sc.com

Prognostic significance of genetic variants in GLUT1 in stage III …

WebThis study tested the hypothesis that GLUT-1 is a marker of radioresistance in oral squamous cell carcinomas (OSCC). A GLUT-1 labeling index (LI) was determined by immunohistochemistry in 40 pretreatment OSCC biopsies. Radiation responses were categorized by histopathology of the resection specimens. Associations between the LI … WebJun 20, 2024 · Overexpression of LAIR-1 in OS cells inhibits Glut1 expression and may further regulate glucose metabolism, thus inhibiting EMT and OS progression. … WebJan 31, 2024 · GLUT1 overexpression is related to poor outcomes in various cancers including NSCLC. 10, 11 In a study by Zhao et al 9., GLUT1 significantly upregulated cyclin A, cyclin D1, cyclin E, cyclin dependent kinase 2 (CDK2), CDK4, CDK6, and matrix metalloproteinase 2, but downregulated p53 and p130 in NSCLC cell lines (A549 and … jed kaffe

Pharmacological Ascorbate Suppresses Growth of Gastric Cancer …

Category:SIRT6 overexpression inhibits cementogenesis by suppressing …

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Glut1 overexpression

Leukemia inhibitory factor drives glucose metabolic ... - Nature

WebJun 1, 2004 · These conclusions are based on 2 hypotheses: (a) Cellular 18 F-FDG uptake is predominantly related to expression of GLUT1, and (b) overexpression of GLUT1 in … WebFeb 15, 2003 · Methods: Retrospective analysis of Glut-1 expression was performed by immunohistology in 118 patients with OSCC, and a Glut-1 labeling index (LI) was …

Glut1 overexpression

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WebGLUT1, a glucose transporter necessary in cementogenesis, was inhibited by SIRT6. Overexpressing GLUT1 in SIRT6-overexpressed OCCM-30 cells rescued the inhibitory effect of SIRT6 on cementoblast differentiation and mineralization. ... Meanwhile, GLUT1 overexpression significantly decreased AMPK activity. Overall, on one hand, SIRT6 … WebNov 20, 2000 · We have recently shown that Glut1 has limited expression in normal tissues but can be detected by immunohistochemistry in a variety of malignant neoplasms, including nonsmall cell lung carcinoma (NSCLC). 24 Glut3 is also expressed in NSCLC. 25 Whereas Glut1 overexpression in colon carcinoma was found to be associated with an increased …

WebApr 13, 2024 · Glucose transporter 1 (GLUT1) is an important transporter in glycolysis, importing glucose into the cytoplasm. In gastric cancer (GC), the long noncoding RNA LINC00958 is highly expressed compared to normal gastric tissues and upregulated level of LINC00958 clinically indicates the poor survival of GC patients. ... KIAA1429 … WebJun 5, 2014 · HIF-1α and GLUT1 are critical for OGT-mediated regulation of metabolic stress as overexpression of stable HIF-1 or GLUT1 rescues metabolic defects and apoptosis. Human basal-like breast cancers with high levels of HIF-1α contain elevated OGT, O-GlcNAcylation and lower OGA levels correlate independently with poor patient …

WebMar 23, 2015 · Overexpression of GLUT1 inhibits cell death triggered by DHA. The data shown above indicated that DHA-induced cytotoxicity in NSCLC cells was associated with inhibition of glucose uptake through down-regulation of GLUT1. Based on above findings, we then asked if overexpression of GLUT1 could rescue DHA-induced apoptosis in … Web13 hours ago · GLUT1 is one of the key molecules responsible for glucose transport and initiating glucose uptake in cells, where it is also involved in the regulation of aerobic glycolysis [39., 40., 41.In CD4 + T cells, decreased expression of GLUT1 decreases the glycolysis level, thus inhibiting their activation [42, 43].TEPP-46 is an allosteric activator …

WebMay 24, 2024 · The GLUT on the cell membrane takes up FDG as well as glucose and phosphorylates it to FDG-6-phosphate by hexokinase. It is known that overexpression …

WebMay 27, 2003 · GLUT-1 is ubiquitously expressed and is the predominant glucose transporter in mesangial cells. In mesangial cells in vitro, GLUT-1 overexpression … lagrangian point wikipediaWebThe overexpression of MYC is directly related to telomerase reactivation and/or telomerase reverse-transcriptase (TERT) upregulation. ... which increases glucose uptake through the induction of GLUT-1, GLUT-4 and GLUT-1; simultaneosly, it can also be stimulated by TGF-β through the PI3K/AKT/mTOR pathway. Other important mediators are p53 that ... lagrangian primal problemWebFeb 28, 2014 · [25][26] [27] In addition, the expression of GLUT1 often correlates with the ability to detect tumors by PET. 49 Overexpression of GLUT1 gene has been shown to confer two-to fivefold higher drug ... lagrangian problems