WebHigh Fidelity is an American romantic comedy television series, based on the 1995 novel High Fidelity by Nick Hornby and the 2000 High Fidelity film.It premiered on the Hulu streaming service on February 14, 2024. … Web27 de jul. de 2024 · Clustered regularly interspaced short palindromic repeats (CRISPR)-Cas13 has drawn broad interest to control gene expression and cell fate at the RNA level in general. Apart from RNA interference mediated by its endonuclease activity, the nuclease-deactivated form of Cas13 further provides a versatile RNA-guided RNA-targeting …

【标题速读】【Ncomm】【biological-sciences】【2024年】【6 ...

Web近年来随着研究的不断深入，越来越多的研究表明Cas13蛋白在真核细胞内同样具备collateral cleavage能力，这造成细胞休眠、细胞生长缓慢、细胞死亡等不良结果。. 基于上述背景，神经所杨辉团队开发了高保真（High … Webdevelopment of high-fidelity Cas13 variants with markedly reduced collateral effects by mutagenesis and demonstrated the feasibility of hfCas13 for efficient on-target RNA … c++ set memory address

A high-fidelity RNA-targeting Cas13 restores paternal

Web14 de ago. de 2024 · This work, entitled “High-fidelity Cas13 variants for targeted RNA degradation with minimal collateral effects,” was published online in Nature … Web1 A high-fidelity RNA-targeting Cas13 restores paternal Ube3a expression and improves motor functions .. 来源：mol ther( P 1525-0016 E 1525-0024 ) 发表时间: 2024/02. Web13 de jan. de 2024 · Hence high-fidelity Cas13 variants with minimal collateral effects have been developed, which could further elevate their utility for targeted degradation of RNAs … dysphagia and medication administration