Higuchi and connors
WebPhase-solubility studies Water solubility studies for both triterpenic acids were conducted by the Higuchi and Connors method [16] using a series of increasing concentrations of OGCD. In this purpose aqueous suspensions of oleanolic acid and ursolic acid, respectively, were prepared in the presence of OGCD in a concentration range of 1 to 300 ...
Higuchi and connors
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WebJan 30, 2024 · According to Higuchi and Connors (1965), the linear host-guest correlation can be classified as linear diagram (A L) type because the straight line had a slope of less than 1 in each compound, i.e., 0.0074, 0.0202 and 0.0266 for curcumin, demethoxycurcumin, and bisdemethoxycurcumin, respectively. The result indicated that one mole of ... WebMar 22, 2024 · We also introduced the Higuchi and Connors method to analyze inclusion complex formed through solubilization and the pharmaceutical benefits that can be gained using CDs. In addition, the practical applications of CDs in nasal, ophthalmic, pulmonary, and rectal drug delivery are also described. CD applications for drug solubilization
WebDec 18, 2024 · Phase solubility test was performed according to the method of Higuchi and Connors [ 24 ]. An excess amount of camphor was added to aqueous CD (HPβCD and HPγCD) solutions, and the suspensions were shaken at RT. After equilibrium was achieved at the end of 48 h, the suspensions were filtered with 0.45 μm membrane filter. WebAug 8, 2024 · The method of Higuchi and Connors proposes that to determine the inclusion constant of a formed complex 1H 4 MGF:1βCD, the phase-solubility diagram, ([H 4 MGF] = …
WebThis was explained by the solubilization theory of Higuchi and Connors. The solubility analysis of the ternary drug/competitor/CyD systems may be particularly useful for … WebT. Higuchi and K. A. Connors, “Phase-Solubility Techniques,” In: C. N. Reilly, Ed., Advances in Analytical Chemistry and Instrumentation, Wiley-Interscience, New York, Vol. 4, 1965, pp. …
WebThis was explained by the solubilization theory of Higuchi and Connors. The solubility analysis of the ternary drug/competitor/CyD systems may be particularly useful for determination of the stability constant of a drug whose physicochemical and spectroscopic analyses are difficult, because they can be calculated by monitoring the solubility ...
WebTypes of phase-solubility diagrams according to Higuchi and Connors [11] showing how the total drug solubility changes with increasing CD concentration. A-type diagrams are … hyperlink blocked in outlookWebFeb 27, 2010 · According to Higuchi and Connors there can be five types of phase-solubility relationship (Fig. 1 ): A L -type where there is a linear relationship between substrate (drug) solubility and ligand (cyclodextrin) concentration and which is interpreted as formation of a complex with m :1 stoichiometry; A P -type, which represents positive deviation … hyperlink base excelWebThe Higuchi窶鼎onnors phase-solubility method8)is very often used to determine K 1:1 , as a part of a formulation study. This method is based on the effect of a complex forming lig- and, e.g.CD, on the solubility of the drug. The intrinsic solu- bility (S 0 ) and the slope of the phase-solubility diagram are then used to calculate K 1:1 hyperlink a word documentWebMar 30, 2024 · The phase solubility study was carried out according to the method of Higuchi and Connors ( Higuchi, & Connors, 1965 ). Specifically, excessive APG (approximately 10 mg) was added to 5 mL of ethanol–water (30:70, v/v) solution containing different concentrations of OMT in the range of 5–300 mM. hyperlink bibliography latexWebPersonal papers of Takeru Higuchi, PP 359. University of Kansas. Kenneth Spencer Research Library. Higuchi and Connors, "Spectrophotometric Detection of the End Point in the Karl Fischer Titration of Water,", 1959, Box: 11, Folder: 110. Personal papers of Takeru Higuchi, PP 359. University of Kansas. Kenneth Spencer Research Library. hyperlink blue colorWebThe present study was aimed to formulate the solid dispersion incorporated microcapsule to improve the dissolution rate and half life of pioglitazone hydrochloride. The solvent evaporation method was used to formulate the solid dispersion resulted increased dissolution rate, bioavailability and stability. Finally increase the half life of the ... hyperlink body 長文WebSolubility profiles by Higuchi and Connors theory. So is the drug intrinsic solubility in cyclodextrin absence 76 . Source publication Alternative Technologies to Improve … hyperlink blockchain