WebThe protein produced from the IRF5 gene, called interferon regulatory factor 5 (IRF5), acts as a transcription factor, which means that it attaches (binds) to specific regions of DNA and helps control the activity of certain genes. WebNov 29, 2024 · Gene/Cytokine IRF5 TLR7 ... (Table 4), this indicates the interplay of those cytokines within the same T helper cell type. The significance of monitoring cytokines profile has been stressed, and it was suggested that cytokines may be used as markers for early detection of flares ...
IRF-5 Promotes Cell Death in CD4 T Cells during Chronic Infection
Web77.4.2.4.1 IRF5. Interferon regulatory factor 5 (IRF5; encoded by IRF5 ), a pivotal transcription factor in the type I IFN pathway, regulates the expression of IFN-dependent genes, inflammatory cytokines and genes involved in apoptosis. IRF5 is one of the most strongly and consistently SLE-associated genes outside the MHC region, conferring a ... chip vowel
Frontiers Therapeutic Targeting of IRFs: Pathway …
The proposed inclusion of IRF5 in the regulation of T-bet through a conserved interaction with DEF6 in T cells will likely have direct implications in our understanding of the control of cytokine release by T cells and the T cell-driven pathogenesis of several autoimmune diseases. See more Th1 effector cells regulate the body's defense against viruses, bacteria and intracellular pathogens and, when properly functional, are vital … See more Th2 effector T cells are involved in the defense against parasitic infections, allergic reactions and the resolution of chronic inflammation (60). Unlike the previously discussed … See more T cell development is highly dependent on the surrounding cytokine environment and is characterized by high degrees of plasticity which, in many cases, can serve a pathogenic role. … See more WebSep 6, 2024 · We took the example of the CD44 + CD4 + T memory cells (Tmems) expressing IL-10 and those expressing other cytokines, such as IFN-γ-producing T helper type 1 cells (Th1), IL-21-producing T follicular helper cells (Tfh), or TNF-α + IFN-γ + IL-2 + IL-21 + lupus-associated T super helper cells (Tsh) , in mouse autoimmunity and aging. WebJan 6, 2011 · Interestingly, while Th1 responses in Irf5-/-mice were severely impaired 4 weeks after infection, expression of IRF-5 was not required during the first 2 weeks of infection, since the frequency of IFNγ-producing CD4 + T-cells in Irf5-/-mice was comparable to WT mice. This observation suggests that IRF-5 is not essential for the early induction ... chip voor bosch motor