Webb18 okt. 2024 · KAT2A was suggested to impact cell survival and differentiation status, but its precise molecular mechanisms of action remain to be elucidated, and it is unclear whether it is required in AML initiation, as well as maintenance. WebbKAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM …
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Webb9 mars 2024 · Deletion of Ulk1 inhibits neointima formation by enhancing KAT2A/GCN5-mediated acetylation of TUBA/alpha-tubulin in vivo. GCN5-mediated regulation of … WebbBrowse KAT2A products, learn KAT2A Information And Facts common name: KAT2A/GCN5. Protein lysine acyltransferase that could act both as a acetyltransferase … passengers subtitles english
KAT2A Antibodies & ELISA Kits, KAT2A/GCN5 Proteins
Webb29 mars 2024 · CCDC101 is a subunit of 2 histone acetyltransferase complexes: the ADA2A (TADA2A; MIM 602276)-containing (ATAC) complex and the SPT3 (SUPT3H; MIM 602947)-TAF9 (MIM 600822)-GCN5 (KAT2A; MIM 602301)/PCAF (KAT2B; MIM 602303) acetylase (STAGA) complex. Webbstatus of Gcn5 and Pcaf genes, i.e., as Gcn5f/fPcaf /, Gcn5f/f, Pcaf /, and WT. When the CRE is active and describing sorted B cells, we indicate Gcn5 /, a knockout status of the gene. The lack of GCN5 and PCAF, and H3K9 acetylation, were validated using Western blot (Figure S1). 3.2. Mice Lacking GCN5 and PCAF in B Cells Possess Small Spleens Webb21 okt. 2024 · Introduction GCN5 ( Kat2a) is a lysine acetyl transferase capable of acetylating and inhibiting PGC-1α activity. As such, it is described as a negative regulator of PGC-1α and subsequently restricts mitochondrial content. tin man allergic reaction