WebMYC is considered as a non-redundant signaling hubs under several important signaling pathways and essential for maintaining PDAC . The significant downregulation of MYC … Web23 mrt. 2024 · A Phase Separation Model of Enhancer Assembly and Function Many molecules bound at enhancers and SEs, such as transcription factors, transcriptional co …
A Phase Separation Model for Transcriptional Control
Web15 mrt. 2024 · In addition, circVAMP3 promoted CAPRIN1 and G3BP1 phase separation in a concentration-dependent manner, leading to the formation of a stress granule, inhibition of c-Myc translation to... Web16 jul. 2024 · MYC is another key gene in the normal balance between HSC self-renewal and differentiation of HSCs [ 49 ]. MYC super-enhancer (SE) locates 1.7 Mb downstream to TSS of the MYC gene, and disruption of this region causes a significantly decreased MYC expression in HSCs and leads to increased differentiation-arrested multipotent progenitors. optimae facebook
Super-enhancers: critical roles and therapeutic targets in …
Web1 apr. 2016 · In summary, MTAR1 is a novel MYC-related lncRNA that contributes to tumor progression by enhancing MYC translation through mediating PABP1/IGF2BPs liquid–liquid phase separation. View Show abstract Web15 jan. 2024 · One relatively new organizational mechanism involves formation of condensates (also called membraneless organelles) through a process called liquid–liquid phase separation (LLPS). LLPS is a spontaneous, thermodynamically driven process in which two co-existing liquid phases emerge from one homogenous mixture. Web10 nov. 2024 · Studies have shown that EBNA2 and EBNALP can be induced to undergo liquid-phase separation in vitro, and can form liquid-like condensates at the … portland or background