Nis symporter
Webb1 juli 2024 · A molecule widely exploited for cancer theranostics is the sodium iodide symporter (NIS). This molecule mediates iodine uptake in differentiated thyroid cells and is the basis for radioiodine... WebbSymporter (NIS) The Na + /I − symporter (NIS), a 618-amino acid membrane glycoprotein that catalyzes the active accumulation of I − into thyroid cells, was …
Nis symporter
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Webb3 maj 2024 · The sodium iodide symporter (NIS) is a plasma membrane glycoprotein localized at the basolateral membrane of thyroid follicular cells mediating the active transport of iodide into the thyroid gland as an important prerequisite for the biosynthesis of thyroid hormones (Fig. 1) [ 1, 2 ]. Webb1 feb. 2014 · NIS (red circle), located on the basolateral surface of the thyrocyte, mediates Na + /I − symport with a 2:1 stoichiometry. The driving force for this process is the Na + …
Webb25 sep. 2024 · Sodium-iodine symporter (NIS) is another known key protein of normal thyroid cell physiology. It is responsible for the active transport of iodide across the basolateral membrane of thyroid cell. NIS function results in a 20- to 40-fold elevation of iodide concentration with respect to the iodide level in circulating blood ( 7 – 9 ). Webb10 feb. 2024 · The molecular characterization of NIS in 1996 and the use of radioactive I-isotopes have led to significant advances in the diagnosis and treatment of thyroid …
Webb1 juli 2001 · As a member of the sodium-dependent transporter family, NIS is an intrinsic membrane protein with 13 putative transmembrane domains, an extracellular amino-terminus, and an intracellular carboxyl-terminus. Webb3 maj 2024 · Cloning of the sodium iodide symporter (NIS) in 1996 has provided an opportunity to use NIS as a powerful theranostic transgene. Novel gene therapy …
WebbResponses to low-dose Cobalt60 radiation, as well as a newly emerged radioiodine therapy target for BC, that is, sodium-iodide symporter (NIS or SLC5A5) protein, are tested. As therapeutic potential of NIS in BC is often limited due to low uptake and fast efflux rate of iodine, the scope of these two radiosensitizers to further improve NIS-mediated 131I …
WebbDOI: 10.3760/cma.j.cn311282-20241023-00589. 摘要. 中国《甲状腺结节和分化型甲状腺癌诊治指南》 (第二版)是在第一版 (2012年版)的基础上进行的修订。. 参与第二版指南修订的国家级学会由4个增加为7个，内分泌科、甲状腺外科、肿瘤科、核医学科、超声医学科和病 … discus fish hole in the headWebbOncolytic virus. An oncolytic virus is a virus that preferentially infects and kills cancer cells. As the infected cancer cells are destroyed by oncolysis, they release new infectious virus particles or virions to help destroy the remaining tumour. [1] [2] Oncolytic viruses are thought not only to cause direct destruction of the tumour cells ... discus fish healthWebb30 maj 2024 · The Na + /I − symporter (NIS), located in the basolateral membrane of thyrocytes, mediates active iodide uptake from the bloodstream to the intracellular … discus fish for sale usaWebbSymporter sodowo-jodowy (NIS) zlokalizowany jest w błonie podstawnej tyreocyta. Jego fizjologiczna rola polega na katalizowaniu aktywnego, sodowo-zależnego transportu jodków z krwi do wnętrza komórki tarczycy. Gen kodujący NIS znajduje się na krótkim ramieniu chromosomu 19 w pozycji 13 (19p13) i składa się z 15 egzonów oraz 14 … discus fish longboardWebb1 feb. 2003 · Abstract. The Na + /I − symporter (NIS) is an integral plasma membrane glycoprotein that mediates active I − transport into the thyroid follicular cells, the first step in thyroid hormone biosynthesis. NIS-mediated thyroidal I − transport from the bloodstream to the colloid is a vectorial process made possible by the selective targeting of NIS to the … discus fish houstonWebb16 jan. 2024 · The sodium iodide symporter (NIS), a transmembrane glycoprotein on the basolateral membrane of thyroid cells that actively participates in sodium and ion co … discus fish postersWebbLane 1: Mouse Stomach tissue lysates; Lane 2: Rat Stomach tissue lysates probed with NIS Polyclonal Antibody, Unconjugated (bs-0448R) at 1:200 dilution and 4\u00b0C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37˚C. 0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. discus fish mating