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Webadministered by subcutaneous injection every 6 months. Anti-fracture effects of denosumab are similar to those of the bisphosphonates, but there is a pronounced loss of anti … WebDec 1, 2011 · When given as a 60 mg subcutaneous injection every six months, compared with placebo, denosumab increases the bone mineral density at the lumbar spine and hip, with associated relative risk reductions of 68% (7.2% vs 2.3%, p<0.001) for vertebral fractures, 20% (8.0% vs 6.5%, p=0.01) for non-vertebral fractures and 40% (1.2% vs 0.7%, … WebOsteoporosis drugs are grouped into two categories: Antiresorptive drugs slow the rate that your body breaks down bone. They include bisphosphonates, denosumab, estrogens, … shower pump