WebNational Center for Biotechnology Information WebDec 11, 2012 · In heart, phospholemman (PLM) inhibits NKA activity by reducing its apparent Na (+) affinity, an effect that is relieved by PLM phosphorylation. The NKA crystal structure suggests regions of PLM-NKA interaction, but the sites important for functional effects in live cells are not known.
Phospholemman Circulation Research
WebDec 18, 2024 · The study carried out by Boguslavskyi et al. illustrated that phospholemman is hypophosphorylated in a mouse model of aging that induces senescent essential hypertension. Phosphorylation of... WebPhospholemman (PLM) is a member of the FXYD ('fix-it') family of proteins many of which have now been identified as tissue-specific regulators of the Na/K ATPase. PLM (FXYD1) is the primary sarcolemmal substrate for PKC and PKA in the heart. We have recently identified PLM as a novel accessory prote … theoretical fallacy
Phospholemman: its role in normal cardiac physiology and
WebAug 6, 2024 · Conclusions. Although holidays are a physical and mental must have, they can have significant negative consequences on football players’ performance and body composition; this, in turn, would influence injury risk and performance at the start of the new season. It is necessary to implement adapted training programs during these periods, … WebMar 1, 2024 · Phospholemman (PLM, also known as FXYD1) is a 72 amino acid transmembrane muscle cell protein 13–15 which forms a stable complex with NKA. 16, 17 The cytosolic C-terminus of PLM bears at least three different phosphorylation sites, one of them Ser68 can be phosphorylated by PKA and protein kinase C. 18–20 PLM tonically … WebPresence or Absence of the Cl− Channel Phospholemman in the Rectal Gland of Sharks: A Comparative Study Feico M.A.H. Schuurmans Stekhoven1,*, Sjoerd E. Wendelaar Bonga1, Tsung-Han Lee2, and Andrew R. Bottrill3 1Department of Animal Ecology and Ecophysiology, Faculty of Science, Radboud University Nijmegen, Heyendaalseweg 135, 6525 AJ … theoretical factors sociology