Webb17 maj 2024 · In this review article, we explore the roles of plakins, particularly plectin, periplakin and envoplakin in disease-states and cancers with emphasis on ovarian … Plectin has been proposed as a biomarker for pancreatic cancer. Although normally a cytoplasmic protein, plectin is expressed on the cell membrane in pancreatic ductal adenocarcinoma (PDAC) and can therefore be used to target PDAC cells. See also. List of target antigens in pemphigus; References Visa mer Plectin is a giant protein found in nearly all mammalian cells which acts as a link between the three main components of the cytoskeleton: actin microfilaments, microtubules and intermediate filaments. In addition, plectin links … Visa mer Plectin can exist in cells as several alternatively-spliced isoforms, all around 500 kDa and >4000 amino acids. The structure of plectin is thought to be a dimer consisting of a central Visa mer Mutations in PLEC have been associated with epidermolysis bullosa simplex with muscular dystrophy. A missense variant of PLEC has been recently proposed as a cause of atrial fibrillation in some populations. Isolated left ventricular non-compaction … Visa mer • Mass spectrometry characterization of one isoform of PLEC at COPaKB. • GeneReviews/NCBI/NIH/UW entry on Epidermolysis Bullosa with Pyloric Atresia Visa mer Studies employing a plectin knockout mouse have shed light on the functions of plectin. Pups died 2–3 days after birth, and these mice exhibited … Visa mer • List of target antigens in pemphigus Visa mer • Pfendner E, Rouan F, Uitto J (Apr 2005). "Progress in epidermolysis bullosa: the phenotypic spectrum of plectin mutations". Experimental Dermatology. 14 (4): 241–9. doi:10.1111/j.0906-6705.2005.00324.x. PMID 15810881. S2CID 27756698 Visa mer
Plectin-1 Targeted Dual-modality Nanoparticles for Pancreatic …
Webb15 mars 2024 · Plectin-1 targeted dual-functional nanoparticle has great potential in pancreatic cancer detection. Molecular-based radiographic tests hold the promise to … WebbName_Araceli Sosa_ BIO-333 Chapter 16 Guide 1. (pgs. 889-892, figs. 16-1, 16-2, and 16-3, panel 16-1) List and briefly describe the three types of cytoskeletal components. cytoskeleton: system of protein filaments in cytoplasm that give the cell shape and capacity for directed movement 1. actin filaments: determine the shape of cells surface … mary who bookshop website
Plectin ensures intestinal epithelial integrity and protects …
WebbPlectin overexpression has been identified in a wide range of cancers because of its involvement in various cellular activities in tumors, such as cell proliferation, survival, … Webb30 aug. 2024 · The cytolinker and scaffolding protein, plectin, has emerged as a potent driver of malignant hallmarks in many human cancers due to its involvement in various … WebbTo confirm the absence of plectin expression in mutant mice on the protein level, skin and muscle tissue homogenates prepared from mutant and wild-type mice were analyzed by immunoblotting using a rabbit anti-plectin antiserum (Figs. 1D and 2D) and monoclonal antibodies to plectin (data not shown), both immunoreactive with the rod domain of the … mary who anointed jesus feet