Plectin网蛋白

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Webb14 okt. 2008 · Description. A form of epidermolysis bullosa, a genodermatosis characterized by recurrent blistering, fragility of the skin and mucosal epithelia, and erosions caused by minor mechanical trauma. EBS5C is an autosomal recessive disorder characterized by severe skin blistering at birth and congenital pyloric atresia. Death … Webb16 maj 2024 · 2024年5月16日讯/生物谷BIOON/---选择性剪接（alternative splicing）是一种转录后调控机制，对转录组和蛋白质组的多样性至关重要。通过增加蛋白水平的复杂性，选择性剪接可以引起细胞的功能变化。众所周知，RNA结构元件在转录后调控过程（包括选择性剪接）中起着关键作用。因此，由RNA二级结构编码的调节信息对选择性剪接决定的 …

EP3439692A4 - ANTIBODIES BINDING PLECTIN-1 AND USES …

Webb20 nov. 2024 · As plectin is a critical regulator for cell cytoarchitecture and motility, we next measured the effects of plectin knock-down on prostate cancer invasion and migration. WebbPlectin is a large, widely expressed protein that crosslinks the intermediate filament and actin cytoskeleton, mechanically stabilizing cells and tissues. Plectin also plays a role in … in addition other ways to say

Plectin is a regulator of prostate cancer growth and metastasis

Webbplectin binding antibodies antibodies binding Prior art date 2016-04-08 Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a … Webb弹性蛋白由二种类型短肽段交替排列构成。一种是疏水短肽赋予分子以弹性;另一种短肽为富丙氨酸及赖氨酸残基的α螺旋，负责在相邻分子间形成交联。弹性蛋白的氨基酸组成似胶原，也富于甘氨酸及脯氨酸，但很少含羟脯氨酸，不含羟赖氨酸，没有胶原特有的Gly-X-Y序列，故不形成规则的三股螺旋 ... WebbPlectin基因敲除抑制了每个器官的转移数量，并降低了整体转移负担。为了深入了解plectin在前列腺癌生长和转移中的作用，研究人员对前列腺癌plectin敲除异种移植组织进行了蛋白质组学分析。基因集富集分析表明，与细胞外基质和层粘连蛋白相互作用有关的蛋白质水平增加，而调节氨基酸代谢、细胞骨架蛋白和细胞应激反应蛋白质水平下降。 … duty free allowance from jersey to uk

Research Paper Plectin-targeted liposomes enhance the therapeutic …

Webb21 mars 2024 · PLEC (Plectin) is a Protein Coding gene. Diseases associated with PLEC include Epidermolysis Bullosa Simplex 5A, Ogna Type and Muscular Dystrophy, Limb … WebbPlectin is a large, widely expressed protein that crosslinks the intermediate filament and actin cytoskeleton, mechanically stabilizing cells and tissues. Plectin also plays a role in the regulation of actin dynamics and acts as a scaffold for signaling molecules (1). duty free allowance indonesiaWebbSubcellular localization of plectin in a myoblast and schematic representation of plectin and its binding partners, with a special focus on direct interaction partners identiﬁed in myoblasts and/or skeletal muscle. (A) Immunoﬂuorescence microscopy of a human primary myoblast using antibodies to plectin (in red) and desmin (in green). duty free allowance iceland

"Webb9 juni 2013 · Plectin is a large, 500-kDa, intermediate filament (IF)-associated protein. It acts as a cytoskeletal crosslinker and signaling scaffold, affecting mechanical as well as dynamic properties of the cytoskeleton. As a member of the plakin family of cytolinker proteins, plectin has a multidomain structure that is responsible for its vast binding … " - Plectin网蛋白

Plectin网蛋白

EP3439692A4 - ANTIBODIES BINDING PLECTIN-1 AND USES …

Plectin is a giant protein found in nearly all mammalian cells which acts as a link between the three main components of the cytoskeleton: actin microfilaments, microtubules and intermediate filaments. In addition, plectin links the cytoskeleton to junctions found in the plasma membrane that structurally connect different cells. By holding these different networks together, plectin pl… Webb使用 Plectin-1 (D6A11) Rabbit mAb（泳道 2）或 Rabbit (DA1E) mAb IgG XP ® Isotype Control #3900（泳道 3）对 U-2 OS 细胞提取物网蛋白-1 进行免疫沉淀。泳道 1 是 10% 输 …

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Webb16 apr. 2014 · Tissue specificity. Detected in eye lens fiber cells (at protein level) ( PubMed: 21745462 ). Expressed at high levels in lung, brain, small intestine, muscle, heart and skin with lower levels found in kidney, liver, uterus, spleen and salivary gland ( PubMed: 10556294 ). 2 publications. WebbPlectin, a versatile cytoskeleton-associated protein of extraordinarily large size, is expressed abundantly in a wide variety of mammalian tissues and cell types. It is particularly prominent in stratified and simple epithelia, various types of muscle, and cells forming the blood–brain barrier ( Wiche 1989; Errante et al. 1994 ).

Webb27 feb. 2024 · Plectin is a giant cytoskeletal crosslinker (also known as a cytolinker) protein of more than 4,500 amino acids. It belongs to the plakin family of giant proteins, including desmoplakin, envoplakin and periplakin. Plectin was first described in 1980 as a polypeptide component that co-purified with the intermediate filament protein vimentin … Webb5 mars 2024 · Plectin, a highly versatile cytolinker protein, provides tissues with mechanical stability through the integration of intermediate filaments (IFs) with cell …

Webb17 feb. 2024 · Plectin is one such cytolinker, containing an N-terminal canonical actin-binding domain (ABD) linked to a C-terminal IF-binding domain (IFBD) through a central rod domain. Webb15 sep. 2013 · Plectin is a versatile cytolinker of the plakin family conferring cell resilience to mechanical stress in stratified epithelia and muscles. It acts as a critical organizer of the cytoskeletal system by tethering various intermediate filament (IF) networks through its C-terminal IF-binding domain (IF …

WebbPlektin (engl.Plectin, kurz PCN oder PLTN), auch Plectin-1 oder Hemidesmosomal protein 1 (HD1), ist ein bei Eukaryoten vorkommendes Protein.Es lässt sich im Zytoplasma nahezu aller eukaryotischen Zellen nachweisen, in großen Mengen jedoch vor allem in Muskel- und Herzmuskelzellen, Hautzellen, Nervenzellen sowie in Zellen der Plazenta. . Plektin ist ein …

Webbplectin 定义细胞质基质中含量丰富的一种蛋白质（300 kDa）。与多种中间丝共存，与中间丝、微管和肌球蛋白粗丝的交联和锚定有关。应用学科细胞生物学（一级学科），细胞 … in addition please find attachedWebbPlectin is a giant cytoskeletal crosslinker and intermediate filament stabilizing protein. Mutations in the human plectin gene (PLEC) cause several rare diseases that are grouped under the term plectinopathies. The most common disorder is autosomal recessive disease epidermolysis bullosa simplex with muscular dystrophy (EBS-MD), which is … in addition otherwiseWebbIdentified in complexes that contain VIM, EZR, AHNAK, BFSP1, BFSP2, ANK2, PLEC, PRX and spectrin (By similarity). Interacts with COL17A1 (PubMed:12482924). 功能: Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such … duty free allowance from switzerland to ukWebb除原位胰腺组织外，Plectin-1在转移性病变包括肝脏、淋巴结和腹膜组织的免疫组化研究中均有显着表达。通过上述研究说明，Plectin-1的表达特点和表达量可用于鉴别胰腺的良恶性病变，可成为特殊的生物标记。 duty free allowance from majorca to uk 2022Webb4 jan. 2024 · Definition. Plectin gehört zur Proteinfamilie der Plakine. Plectin kommt bei Eukaryoten vor, so auch beim Menschen. Plectin ist ein 500 kDa großes an intermediäre Filamente bindendes Strukturprotein, das im Zytoplasma nahezu aller Zellen nachweisbar ist, so v.a. in Muskel- und Herzmuskelzellen, in Epidermiszellen, Nervenzellen sowie in ... duty free allowance into thailandhttp://fund.keyanzhiku.com/Index/info/id/OTEwMDIxMTUwYmllLXNoaS1sZS1xdS1iaWUtcmVuLWppYS1wYS1zaHUtanUtYmE%3D.html duty free allowance thailandWebb解决办法. 降低一抗浓度，增加洗膜时间和次数。. a.一抗/二抗浓度配比不合适：杂带多，大概率是抗体特异性不好，也有可能抗体浓度太高，可尝试降低一抗浓度进行实验。. b.封闭液问题：配制封闭液所用的脱脂奶粉应选用无防腐剂实验专用脱脂奶粉。. c.洗 ... duty free allowance into ireland