Shared eqtl
Webb4 apr. 2024 · Using genome-wide genetic variation and gene expression datasets, genome-wide association studies (GWASs) can be used to map expression quantitative trait loci (eQTL) and reveal important genetic determinants for variations in gene expression. eQTL can be present within the same locus showing variation in gene expression ( cis -eQTL), … Webb4 mars 2024 · We find strong evidence that the T cell eQTL and CD62L intensity trait association are shared, suggesting a distinct mode of regulation in different cell types …
Shared eqtl
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WebbA tag already exists with the provided branch name. Many Git commands accept both tag and branch names, so creating this branch may cause unexpected behavior. Webb1 maj 2013 · Between the two environments 401 expression traits had an eQTL in both environments, of which 109 had an eQTL within 20 cM ( Table 1 and Figure 2 ). Of the 109 eQTL with a shared location between environments, 20 were among the 50 most significant eQTL in both environments.
Webb9 jan. 2024 · Although most cis -eQTLs were shared between most bulk tissues, the analysis of purified cell types identified a greater diversity of cell-type-specific eQTLs, a … Webb23 nov. 2024 · To disentangle the shared eQTL signal for IL10RB and IFNAR2, we conducted phenome-wide association scans and pathway enrichment analysis, which suggested that IFNAR2 is more likely to play a role in COVID-19 hospitalization. Our findings prioritize trials of drugs targeting IFNAR2 and ACE2 for early management of …
Webb17 juli 2024 · For example, 30 genes shared an eQTL interaction between HAP1 and KRE33, 14 genes shared an eQTL interaction between HAP1 and MKT1, 13 genes shared an eQTL interaction between KRE33 with IRA2, and 14 genes shared eQTL interactions between GPA1 and the mating-type locus (Brem et al., 2005). Webb26 jan. 2024 · The discovery of expression quantitative trait loci (eQTLs) and their target genes (eGenes) has not only compensated for the limitations of genome-wide association studies for complex phenotypes but has also provided a basis for predicting gene expression. Efforts have been made to develop analytical methods in statistical genetics, …
Webb1 aug. 2013 · We next examined the hypothesis that the CRE landscape is a major determinant of eQTL specificity, and found that eQTL SNPs that overlap cell type specific CREs are more likely to be cell type specific than are eQTL SNPs that overlap shared CREs (Fisher's exact test ) for , , and CRE data sets in LCLs, liver, and cerebellum, respectively …
Webb2 juni 2024 · cis-eQTL data used in this study was derived from a meta-analysis of cis-eQTL’s between independent brain and blood samples . The exact meta-analysis cis … op shop normanvilleWebb10 feb. 2024 · Expression quantitative trait loci (eQTL) studies offer a systematic approach to identify such cis -regulatory elements by correlating the genotypes of genomic variants segregating in individuals … porter\u0027s wild alaskaWebb16 juli 2024 · An expression quantitative trait locus (eQTL) is a genetic locus where sequence variation is associated with altered expression of one or more genes. eQTL … portera wilsonville oregonWebb30 nov. 2024 · The SLE-risk alleles demonstrated significantly more eQTLs in NCLs as compared to CLs (p = 0.0004). There were 18 eQTLs exclusive to NCL cells, 5 eQTLs … op shop noosavilleWebbWe found that cis-eQTL signals (within 1 Mb of their target gene) were numerous, and many acted heterogeneously among regions and exons. Co-regulation analysis of shared eQTL signals produced well-defined modules of region-specific co-regulated genes, in contrast to standard coexpression analysis of the same samples. porterandyork.comWebb27 apr. 2024 · The 386 distinct eGenes in shared eQTL pairs in significant blood and brain results were further examined for differentially expressed genes (DEG) between AD … op shop north perthWebb2 juni 2024 · Summary-data-based Mendelian Randomization (SMR) addresses this problem through an instrumental variable approach that integrates data from independent GWAS and expression quantitative trait locus (eQTL) studies in order to infer a causal effect of gene expression on a trait. Results op shop northam