Siglec 10 antibody
WebPRO940 antibody, SIGLEC-10 antibody, SLG2 antibody, Siglecg antibody, SIGLEC10 antibody, slg2 antibody, pro940 antibody, siglec-10 antibody, sialic acid binding Ig like … WebAbcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that …
Siglec 10 antibody
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Like most but not all other Siglecs, Siglec-10 bears an ITIM (Immunoreceptor tyrosine-based inhibitory motif) within its cytoplasmic domain. Siglec-10 is a ligand for CD52, the target of the therapeutic monoclonal antibody Alemtuzumab. It is also reported to bind to Vascular adhesion protein 1 (VAP-1) and to … See more Sialic acid-binding Ig-like lectin 10 is a protein that in humans is encoded by the SIGLEC10 gene. Siglec-G is often referred to as the murine paralog of human Siglec-10 See more SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor … See more • Li N, Zhang W, Wan T, et al. (2001). "Cloning and characterization of Siglec-10, a novel sialic acid binding member of the Ig superfamily, from human dendritic cells". J. Biol. Chem. 276 (30): 28106–12. doi:10.1074/jbc.M100467200. PMID 11358961. See more WebNov 10, 2024 · AK007 is a humanized Siglec-10 antagonist antibody designed to block Siglec-10 interaction with all known ligands (CD24, CD52, and VAP-1). By targeting Siglec …
WebMonoclonal Anti-Siglec-10 antibody produced in mouse. clone 1D11, purified immunoglobulin, buffered aqueous solution. View Price and Availability. Sigma-Aldrich. … WebSIGLEC10 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. It preferentially binds to alpha2,3- or 2,6-linked sialic acid. The sialic acid recognition …
WebJun 10, 2024 · High infiltration of Siglec-10 hi TAMs was associated with impaired CD8 + T cell function in HCC. Of note, blocking Siglec-10 with the competitive binding antibody … WebIn cancer it is important to consider the mode of action of CD24-Fc. The binding to Siglec-10 on immune effector cells as an agonist could render cells more immunosuppressive. In …
WebSIGLEC10 antibody LS-C325111 is an unconjugated rabbit polyclonal antibody to human SIGLEC10 (aa667-695). Validated for ELISA and WB. Products. Research Areas. COVID-19. Resources. ... SIGLEC10 SIGLEC-10 Siglec-like gene 2 Siglec-like protein 2 PRO940 SLG2. See All SIGLEC10 Antibodies. Host. Rabbit.
WebNov 29, 2024 · Summary. Siglec-9 is an immune checkpoint target and an immunoinhibitory receptor that can engage either sialic acid ligands or agonistic antibodies. Through Siglec … phimosis foleyWebThe cell-expression patterns are indicated on the basis of antibody labelling, except for Siglec-14 and Siglec-15, which have not yet been determined. The brackets indicate low … tsm business review impact factorWebFlow cytometric analysis of Siglec-10 expression on human peripheral blood lymphocytes. Human whole blood was stained with Alexa Fluor® 488 Mouse Anti-Human CD19 antibody (Cat. No. 555412) and either BD Horizon™ BV421 Mouse IgG1, κ Isotype Control (Cat. No. 562438; Left Plot) or BD Horizon BV421 Mouse Anti-Human Siglec-10 antibody (Cat. No. … tsm business school enschedeWebNov 29, 2024 · Summary. Siglec-9 is an immune checkpoint target and an immunoinhibitory receptor that can engage either sialic acid ligands or agonistic antibodies. Through Siglec-9 sialic acid interactions, activated immunoreceptor tyrosine-based inhibitory signaling of the immune cells can lead to unfavorable immunosuppression. phimosis handoutWebJul 4, 2014 · Siglec-10 (human homolog of mouse Siglec-G) was detected on all B cells and also subsets of human leukocytes including eosinophils, monocytes and a minor … tsm bullyingWebMay 20, 2024 · Indeed, B-cell activation by antibodies to the B-cell receptor IgD is dramatically suppressed by conjugation of anti-IgD with high affinity ligands of a B-cell … tsm bulk carriersWebSiglec-10 is a sialic acid-binding Ig-like lectin that has been shown to negatively regulate innate and adaptive immune system function (1). Siglec-10 is a type 1 transmembrane protein that has four extracellular Ig-like domains, a transmembrane region, and a cytoplasmic tail with two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) (2). tsm building