Slc40a1 macrophage
WebAug 13, 2024 · M2 macrophages, which resemble tumor-associated macrophages, express iron-efflux genes with increased SLC40A1 and decreased ferritin . When cultured with … WebSep 13, 2024 · By comparing human and mouse, we have recently suggested a core gene signature specific to KCs (Table 1), including CD5L, VSIG4, CD163, FOLR2, MARCO, and …
Slc40a1 macrophage
Did you know?
WebNov 6, 2024 · HGNC Approved Gene Symbol: SLC40A1 Cytogenetic location: 2q32.2 Genomic coordinates (GRCh38): 2:189,560,590-189,580,786 (from NCBI) Gene-Phenotype Relationships PheneGene Graphics TEXT Cloning and Expression Defects in iron absorption and utilization lead to iron deficiency and overload disorders. WebBackgroundIt has been shown that tumor-associated immune cells, particularly macrophages, play a fundamental role in the development and treatment response of intrahepatic cholangiocarcinoma (ICC). However, little is known about macrophages at the single cellular level of ICC patients.MethodsScRNA-seq from Zhang et al. was used in the …
WebJan 24, 2024 · The major source of this iron is a recycling pathway where macrophages scavenge old and damaged erythrocytes to release iron contained within the heme moiety. Macrophages also promote erythropoiesis by providing a supportive niche in the bone marrow as an integral component of "erythorblastic islands." WebNov 21, 2024 · The presence and positive correlation of F13A1 with macrophage marker ITGAM (Integrin αM; CD11b) to F13A1 (Fig. 3E) suggests this link, but also indicates the presence of macrophages in the ...
WebSep 29, 2024 · SLC40A1 and TMPRSS6 SNPs might act in the opposite direction, preventing the development of severe iron overload, and the modulation of the iron status by TMPRSS6 SNPs might provide protection. ... macrophage recycling, and liver storage and iron requirements for oxygen transport, the immune system, and cognitive functions. ... WebThe SLC40A1 gene is associated with autosomal dominant ferroportin disease (aka hemochromatosis type 4 (HFE4)) (MedGen UID: 340044). Providers. Providers Home. …
WebJan 24, 2024 · Abbreviations: RBC, red blood cells; ROS, reactive oxygen species; FPN, ferroportin (Slc40A1); HO-1, heme oxygenase-1. Heme is taken up by macrophages by …
WebFerroportin is a 12-transmembrane domain protein, belonging to the major facilitator superfamily of transporters of small molecules, that is localized to the plasma membrane.Human Ferroportin has a theoretical molecular … harris county auditor\u0027s office vendor paymentWebMacrophages of the reticuloendothelial system; Adipocytes; Role in development. Ferroportin-1 plays an important role in neural tube closure and forebrain patterning. … harris county attorney jobsWebIt is known that ferroportin (SLC40A1) gene is expressed at a low level in infertile women. Its mRNA levels were discovered to be down-regulated in these women, specifically in granulosa cells. What's more, low expression of ferroportin is also associated with infertility when some features like age and smoking habits are considered. harris county auditor\u0027s office jobsWebFeb 9, 2024 · Quantification of monocytes and macrophages revealed that clusters CD52 mono, IRF1 mono, SERPINB2 mono, C1QC macro, and SLC40A1 macro were expanded in liver tissues and PBMCs of patients with alcoholic cirrhotic livers (P < 0.05) ( Figures 2B, E ). charged dash poe wikiWebThe SLC40A1 gene encodes ferroportin, a protein responsible for exporting iron from cells in the intestine, liver, spleen, and kidney, as well as from reticuloendothelial macrophages and the placenta. [6] [7] More than 39 mutations to the SLC40A1 gene have been identified in patients with type 4 hemochromatosis. [7] harris county auditor\u0027s office formsWebOct 15, 2024 · In addition to binding sites for the general macrophage LDTFs PU.1 and C/EBPs, ... Slc40a1, C1qa, Acp5, and P2ry13 (Figures 5 F and S5 B). A similar effect of DLL4 was also observed in BM monocytes, in which 90 KC identity genes were induced by DLL4 stimulation for 48 h (Figure S5 C). Collectively, these findings indicate that DLL4 is … charged cushioning vs micro gWebSLC40A1 is an iron-regulated transporter assumed to play roles in intestinal iron absorption and cellular iron release. It mediates iron efflux in the presence of ferroxidase. Defects in … charged deathly shocker mhw iceborne