Thermosensitive in situ gel
Webb23 mars 2024 · A thermosensitive gel that exhibits lower critical solution temperature (LCST) becomes hydrophilic at low temperatures and hydrophobic at high temperatures in water. A system for absorbing hydrophobic organic matters that exploits this property has been reported. While washing the gel at a low temperature with a good solvent is a … WebbThe aim of this study was to develop optimized simvastatin (SMV) solid lipid nanoparticles (SLNs) with subsequent loading into a thermosensitive in situ gel (ISG) to enhance and control intranasal drug permeation. Three formulation factors were optimized for their effect on particle size and entrapment efficiency (EE).
Thermosensitive in situ gel
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WebbPurpose: Thermosensitive in situ gels have been around for decades but only a few have been translated into ophthalmic pharmaceuticals. The aim of this study was to combine … Webb1 juli 2012 · These gels were prepared by addition of mucoadhesive polymers (0.5%) to the formulations of thermosensitive gelling solution containing poloxamer 407 (18%) and …
Webb26 maj 2024 · Viability assay on retinal cells displayed that fluconazole nanoemulsion in-situ gel formulation was non-toxic and can be safely used in the eye at concentrations of 0.1% and 0.5%. ... Z. Development of thermosensitive in situ gel nanoemulsions for ocular delivery of acyclovir. J Drug Deliv Sci Technol 2024; 55: 101400. Google Scholar Webb1 juli 2012 · The results concluded that thermosensitive liquid in-situ gelling suppositories of Metoclopramide Hydrocloride were effective, potential, and more convenient alternative for a conventional oral dosage form that was given for emetic patients; thereby improving patient compliance and medication adherencet. 3 PDF View 1 excerpt, cites methods
Webb7 feb. 2024 · The aim of this work was to formulate an ST rectal hydrogel. Methods: Hydrogels were formulated according to a Box–Behnken design using pluronic F-127 (PF-127) and chitosan as thermogelling and mucoadhesive agents, respectively. The rectal permeability was examined using a sheep rectal mucosa. WebbThe study's goal was to create an in situ intrarectal mucoadhesive gel of sumatriptan (SMT) combining mucoadhesive polymer (xyloglucan) and thermosensitive polymers (poloxamer 407 and poloxamer 188) to prolong rectal residence time for …
Webb1 feb. 2024 · The aim of the current study was to formulate thermosensitive in situ gel nanoemulsions (NEs) containing acyclovir (ACV) for ocular drug delivery and evaluate their ex vivo corneal permeation ability and ocular irritation possibility. ACV loaded NEs were prepared by low energy method.
Webb28 feb. 2024 · Enhanced photo/chemo combination efficiency against bladder tumor by encapsulation of DOX and ZnPC into in situ-formed thermosensitive polymer hydrogel Zhongming Huang Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China, … hager door pull catalogWebb2 juni 2024 · This research focuses on the temperature-sensitive in-situ gel with LC as the main drug (LCTG) and the in vitro release and eye irritation of the preparation were investigated. The comparison between LC solution and LCTG was made to verify the rationality of the choice of the dosage form. hager domestic catalogueWebb7 maj 2016 · phase transition from sol-to-gel phase in situ gelling systems can be categorized into following three types:11,18 pH triggeredin situ gelling polymers:pH triggered in situ gelling systems are solutions, which upon exposure to the pH of the lachrymal fluid converts into the gel phase e.g. such as cellulose acetate bramhall street warringtonWebbThermosensitive gel: In situ gel was formulated using methanolic and aqueous extracts of Poloxamer 407 and poloxamer 188 with hydroxy propyl methyl cellulose (HPMC) K100 M … bramhall sixth formWebbBiodegradable and injectable in situ thermosensitive hydrogels were investigated for sustained delivery of pro- tein therapeutics in the treatment of ocular posterior segment neovascular diseases. A series of triblock (TB, polycaprolac- tone-polyethylene glycol-polycaprolactone (PCL-PEG-PCL), B-A-B) and pentablock copolymers (PBCs) (polylactic … bramhall sorting office phone numberWebb18 dec. 2024 · This study aims to formulate and evaluate the temperature-sensitive in situ gel of 0.5% ( w / v) azithromycin (AZM) containing cyclodextrin inclusion complex by the cold method. Method To increase its aqueous solubility, it was incorporated as an inclusion complex in a 1:1 M ratio with hydroxypropyl β-cyclodextrin (HPβ-CD). hager distributor singaporeWebbThermosensitive in situ gel preparations can be applied to nasal, ophthalmic, injection, and vaginal preparations, with the aim to increase the contact time of the formulation when it is applied. Keywords: Thermosensitive in situ gel, Poloxamer, Kitosan, Nasal, Ophthalmic, Injection, Vaginal. Abstrak. bramhalls solicitors