Thiotepa package insert pdf
WebSep 6, 2024 · Thiotepa may be given by rapid intravenous administration in doses of 0.3 to 0.4 mg/kg. Doses should be given at 1 to 4 week intervals. The dosage recommended is 0.6 to 0.8 mg/kg. Administration is usually effected through the same tubing which is used to remove the fluid from the cavity involved. WebPharmacy Bulk Package: Prepare doses for more than one patient in a Pharmacy Admixture Service under appropriate conditions for cytotoxic drugs. Do not inject entire contents of vial directly into patients. Use within 4 hours of puncture (2.7, 2.8) ----- DOSAGE FORMS AND STRENGTHS -----
Thiotepa package insert pdf
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WebApproval Package for: APPLICATION NUMBER: 208264Orig1s000 Trade Name: TEPADINA Generic Name: thiotepa Sponsor: Adienne SA Approval Date: January 26, 2024 Indications: TEPADINA is indicated to reduce the risk of graft rejection when used in conjunction with high-dose busulfan and cyclophosphamide as a preparative WebThiotepa has the molecular formula CH NPS, and a molecular weight of 189.22. When reconstituted with sterile water for injection, the resulting solution has a pH of …
WebOct 15, 2024 · Thiotepa impaired fertility in male mice at PO or IP doses ≥ 0.7 mg/kg (2.24 mg/m 2), approximately 12-fold less than the maximum recommended human therapeutic dose based on body-surface area. Thiotepa (0.5 mg) inhibited implantation in female rats when instilled into the uterine cavity. WebJan 5, 2024 · Thiotepa for injection is indicated for controlling intracavitary effusions secondary to diffuse or localized neoplastic diseases of various serosal cavities. 1.4 …
WebFeb 20, 2024 · The administration of thiotepa with cyclophosphamide in patients reduces the conversion of cyclophosphamide to the active metabolite, 4 … WebThiotepa can cause fetal harm when administered to a pregnant woman. Thiotepa given by the intraperitoneal (IP) route was tera-togenic in mice at doses ≥ 1 mg/kg (3.2 mg/m2), …
WebApproval Package for: APPLICATION NUMBER: 208264Orig1s000 Trade Name: TEPADINA Generic Name: thiotepa Sponsor: Adienne SA Approval Date: January 26, 2024 …
WebOct 15, 2024 · Thiotepa is a cytotoxic agent of the polyfunctional type, related chemically and pharmacologically to nitrogen mustard. The radiomimetic action of thiotepa is … tattoo shops in billingsWebThiotepa for injection is indicated for treatment of adenocarcinoma of the breast or ovary. 1.3 Malignant Effusions Thiotepa for injection is indicated for controlling intracavitary effusions secondary to diffuse or localized neoplastic diseases of various serosal cavities. 1.4 Superficial Papillary Carcinoma of the Urinary Bladder the caring relation in teachingWebIndividuals are exposed to thiotepa during its use in cancer therapy. Thiotepa has been administered through various parenteral routes (e.g., intravenous, intramuscular, intrathecal, and intratumoral); gen-erally, adjustment of the dosage is based on changes in leukocyte counts. Thiotepa is available in injectable form in solutions contain- the caring place personal care franklin pahttp://www.ntp.niehs.nih.gov/ntp/roc/content/profiles/thiotepa.pdf tattoo shops in beloit wiWebNov 1, 2024 · 5.3 Cutaneous Toxicity. Thiotepa and/or its active metabolites may be excreted in part via skin patients receiving high-dose therapy. Treatment with thiotepa may cause skin discoloration, pruritus, blistering, desquamation, and peeling that may be more severe in the groin, axillae, skin folds, in the neck area, and under dressings. the caring reaperWebThiotepa (thye oh tep' a) is a drug that is used to treat many types of cancer. It is a clear liquid that is injected into your spine (intrathecal) or into a device implanted under the skin on the top of your head (Ommaya reservoir). • Tell your doctor if you have ever had an unusual or allergic reaction to thiotepa before receiving thiotepa. • tattoo shops in billings mtWebThiotepa impaired fertility in male mice at PO or IP doses ≥ 0.7 mg/kg (2.24 mg/m), approximately 12-fold less than the maximum recommended human therapeutic dose based on body-surface area. Thiotepa (0.5 mg) inhibited implantation in female rats when instilled into the uterine cavity. Thiotepa interfered with spermatogenesis in mice at tattoo shops in billings montana